Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation

BACKGROUND: Proteins involved in the DNA damage response accumulate as microscopically-visible nuclear foci on the chromatin flanking DNA double-strand breaks (DSBs). As growth of ionizing radiation (IR)-induced foci amplifies the ATM-dependent DNA damage signal, the formation of discrete foci plays...

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Detalles Bibliográficos
Autores principales: Ishikawa, Aya, Yamauchi, Motohiro, Suzuki, Keiji, Yamashita, Shunichi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924841/
https://www.ncbi.nlm.nih.gov/pubmed/20684759
http://dx.doi.org/10.1186/2041-9414-1-10

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