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Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

BACKGROUND: The PI3K-Akt signal pathway plays a key role in tumorigenesis and the development of drug-resistance. Cytotoxic chemotherapy resistance is linked to limited therapeutic options and poor prognosis. METHODOLOGY/PRINCIPAL FINDINGS: Examination of FOXO3a and phosphorylated-Akt (P-Akt) expres...

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Detalles Bibliográficos
Autores principales:	Chen, Jie, Gomes, Ana R., Monteiro, Lara J., Wong, San Yu, Wu, Lai Han, Ng, Ting-Ting, Karadedou, Christina T., Millour, Julie, Ip, Ying-Chi, Cheung, Yuen Nei, Sunters, Andrew, Chan, Kelvin Y. K., Lam, Eric W.-F., Khoo, Ui-Soon
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924889/ https://www.ncbi.nlm.nih.gov/pubmed/20808831 http://dx.doi.org/10.1371/journal.pone.0012293

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