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Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role of NLRP3 (NALP3), its adaptor protein PYCARD (ASC), and caspase-1 during infection with Mycobacterium tuberculosis (Mtb). Mtb infection of mac...

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Detalles Bibliográficos
Autores principales:	McElvania TeKippe, Erin, Allen, Irving C., Hulseberg, Paul D., Sullivan, Jonathan T., McCann, Jessica R., Sandor, Matyas, Braunstein, Miriam, Ting, Jenny P.-Y.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924896/ https://www.ncbi.nlm.nih.gov/pubmed/20808838 http://dx.doi.org/10.1371/journal.pone.0012320

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