Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss

BACKGROUND: Hyperparathyroidism in humans and continuous parathyroid hormone (cPTH) treatment in mice cause bone loss by regulating the production of RANKL and OPG by stromal cells (SCs) and osteoblasts (OBs). Recently, it has been reported that T cells are required for cPTH to induce bone loss as t...

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Detalles Bibliográficos
Autores principales: Tawfeek, Hesham, Bedi, Brahmchetna, Li, Jau-Yi, Adams, Jonathan, Kobayashi, Tatsuya, Weitzmann, M. Neale, Kronenberg, Henry M., Pacifici, Roberto
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924900/
https://www.ncbi.nlm.nih.gov/pubmed/20808842
http://dx.doi.org/10.1371/journal.pone.0012290

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