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Capture of a Transition State Using Molecular Dynamics: Creation of an Intercalation Site in dsDNA with Ethidium Cation
The mechanism of intercalation and the ability of double stranded DNA (dsDNA) to accommodate a variety of ligands in this manner has been well studied. Proposed mechanistic steps along this pathway for the classical intercalator ethidium have been discussed in the literature. Some previous studies i...
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| Formato: | Texto |
| Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925101/ https://www.ncbi.nlm.nih.gov/pubmed/20798766 http://dx.doi.org/10.4061/2010/702317 |