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The Avian Proghrelin System

To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure...

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Detalles Bibliográficos
Autores principales: Richards, Mark P., McMurtry, John P.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925213/
https://www.ncbi.nlm.nih.gov/pubmed/20798876
http://dx.doi.org/10.1155/2010/749401
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author Richards, Mark P.
McMurtry, John P.
author_facet Richards, Mark P.
McMurtry, John P.
author_sort Richards, Mark P.
collection PubMed
description To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system. These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues. Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it. While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals. This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system. Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system.
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spelling pubmed-29252132010-08-26 The Avian Proghrelin System Richards, Mark P. McMurtry, John P. Int J Pept Review Article To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system. These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues. Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it. While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals. This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system. Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system. Hindawi Publishing Corporation 2010 2010-02-10 /pmc/articles/PMC2925213/ /pubmed/20798876 http://dx.doi.org/10.1155/2010/749401 Text en Copyright © 2010 M. P. Richards and J. P. McMurtry. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Richards, Mark P.
McMurtry, John P.
The Avian Proghrelin System
title The Avian Proghrelin System
title_full The Avian Proghrelin System
title_fullStr The Avian Proghrelin System
title_full_unstemmed The Avian Proghrelin System
title_short The Avian Proghrelin System
title_sort avian proghrelin system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925213/
https://www.ncbi.nlm.nih.gov/pubmed/20798876
http://dx.doi.org/10.1155/2010/749401
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