Cargando…
The increase of plasma galectin-9 in a patient with insulin allergy: a case report
Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old pat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925330/ https://www.ncbi.nlm.nih.gov/pubmed/20699002 http://dx.doi.org/10.1186/1476-7961-8-12 |
_version_ | 1782185664719093760 |
---|---|
author | Chagan-Yasutan, Haorile Shiratori, Beata Siddiqi, Umme Ruman Saitoh, Hiroki Ashino, Yugo Arikawa, Tomohiro Hirashima, Mitsuomi Hattori, Toshio |
author_facet | Chagan-Yasutan, Haorile Shiratori, Beata Siddiqi, Umme Ruman Saitoh, Hiroki Ashino, Yugo Arikawa, Tomohiro Hirashima, Mitsuomi Hattori, Toshio |
author_sort | Chagan-Yasutan, Haorile |
collection | PubMed |
description | Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/μl, 17.6 fold) and a moderate increase of IgE (501 U/ml, reference range: 10-350 U/ml), eotaxin-3 (168 pg/ml, 2 fold), histamine (0.95 ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,480/μl; 7.3 fold), and OPN (1.4 fold) still occurred but the GAL-9 levels became normal. Therefore, we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately. |
format | Text |
id | pubmed-2925330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29253302010-08-24 The increase of plasma galectin-9 in a patient with insulin allergy: a case report Chagan-Yasutan, Haorile Shiratori, Beata Siddiqi, Umme Ruman Saitoh, Hiroki Ashino, Yugo Arikawa, Tomohiro Hirashima, Mitsuomi Hattori, Toshio Clin Mol Allergy Case Report Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/μl, 17.6 fold) and a moderate increase of IgE (501 U/ml, reference range: 10-350 U/ml), eotaxin-3 (168 pg/ml, 2 fold), histamine (0.95 ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,480/μl; 7.3 fold), and OPN (1.4 fold) still occurred but the GAL-9 levels became normal. Therefore, we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately. BioMed Central 2010-08-11 /pmc/articles/PMC2925330/ /pubmed/20699002 http://dx.doi.org/10.1186/1476-7961-8-12 Text en Copyright ©2010 Chagan-Yasutan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Chagan-Yasutan, Haorile Shiratori, Beata Siddiqi, Umme Ruman Saitoh, Hiroki Ashino, Yugo Arikawa, Tomohiro Hirashima, Mitsuomi Hattori, Toshio The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title | The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title_full | The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title_fullStr | The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title_full_unstemmed | The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title_short | The increase of plasma galectin-9 in a patient with insulin allergy: a case report |
title_sort | increase of plasma galectin-9 in a patient with insulin allergy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925330/ https://www.ncbi.nlm.nih.gov/pubmed/20699002 http://dx.doi.org/10.1186/1476-7961-8-12 |
work_keys_str_mv | AT chaganyasutanhaorile theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT shiratoribeata theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT siddiqiummeruman theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT saitohhiroki theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT ashinoyugo theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT arikawatomohiro theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT hirashimamitsuomi theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT hattoritoshio theincreaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT chaganyasutanhaorile increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT shiratoribeata increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT siddiqiummeruman increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT saitohhiroki increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT ashinoyugo increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT arikawatomohiro increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT hirashimamitsuomi increaseofplasmagalectin9inapatientwithinsulinallergyacasereport AT hattoritoshio increaseofplasmagalectin9inapatientwithinsulinallergyacasereport |