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The kinetics of two dimensional TCR and pMHC interactions determine T cell responsiveness

The T cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC) to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct physical contact is required between the T cell and the antigen-presenting cell (APC) for cross-junctional binding whe...

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Detalles Bibliográficos
Autores principales:	Huang, Jun, Zarnitsyna, Veronika I., Liu, Baoyu, Edwards, Lindsay J., Jiang, Ning, Evavold, Brian D., Zhu, Cheng
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925443/ https://www.ncbi.nlm.nih.gov/pubmed/20357766 http://dx.doi.org/10.1038/nature08944

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