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Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

BACKGROUND: Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may...

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Detalles Bibliográficos
Autores principales:	Durrmeyer, Xavier, Hovhannisyan, Shushanik, Médard, Yves, Jacqz-Aigrain, Evelyne, Decobert, Fabrice, Barre, Jérome, Alberti, Corinne, Aujard, Yannick, Danan, Claude, Baud, Olivier
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925896/ https://www.ncbi.nlm.nih.gov/pubmed/20808793 http://dx.doi.org/10.1371/journal.pone.0012329

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