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Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder resulting in large kidney cysts and eventual kidney failure. Mutations in either the PKD1 or PKD2/TRPP2 genes and their respective protein products, polycystin-1 (PC1) and polycystin-2 (PC2) result in ADPKD. PC2 is known to f...

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Detalles Bibliográficos
Autores principales:	Woodward, Owen M., Li, Yun, Yu, Shengqiang, Greenwell, Patrick, Wodarczyk, Claas, Boletta, Alessandra, Guggino, William B., Qian, Feng
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925899/ https://www.ncbi.nlm.nih.gov/pubmed/20808796 http://dx.doi.org/10.1371/journal.pone.0012305

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