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The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents

BACKGROUND: Propofol and remifentanil are used for tracheal intubation in the absence of neuromuscular blocking agents. We hypothesized that the addition of sevoflurane to propofol and remifentanil would improve intubation conditions and provide hemodynamic stability. METHODS: Seventy-six patients s...

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Autores principales: Kim, Wook Jong, Choi, Seong Soo, Kim, Doo Hwan, Seo, Hye Jeong, Suk, Eun Ha, Ku, Seung Woo, Park, Pyung Hwan
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926435/
https://www.ncbi.nlm.nih.gov/pubmed/20740212
http://dx.doi.org/10.4097/kjae.2010.59.2.87
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author Kim, Wook Jong
Choi, Seong Soo
Kim, Doo Hwan
Seo, Hye Jeong
Suk, Eun Ha
Ku, Seung Woo
Park, Pyung Hwan
author_facet Kim, Wook Jong
Choi, Seong Soo
Kim, Doo Hwan
Seo, Hye Jeong
Suk, Eun Ha
Ku, Seung Woo
Park, Pyung Hwan
author_sort Kim, Wook Jong
collection PubMed
description BACKGROUND: Propofol and remifentanil are used for tracheal intubation in the absence of neuromuscular blocking agents. We hypothesized that the addition of sevoflurane to propofol and remifentanil would improve intubation conditions and provide hemodynamic stability. METHODS: Seventy-six patients scheduled for elective surgery were randomly allocated to be ventilated with either 4% (group I) or 7% sevoflurane (group II) after propofol injection (2 mg/kg). All patients received remifentanil (1 µg/kg) 30 seconds after administration of propofol. Ninety seconds after remifentanil was given, laryngoscopy and tracheal intubation were performed. Intubation conditions and hemodynamic changes were evaluated. RESULTS: The overall incidence of clinically acceptable intubation conditions was significantly higher in group II (92%) than group I (58%) (P = 0.001). Scores for vocal cord position, coughing, and limb movement were significantly better in group II (P < 0.05). Mean blood pressure remained significantly lower than the pre-induction level throughout the investigation in both groups (P < 0.001), but there was no incidence of bradycardia or hypotension requiring treatment. CONCLUSIONS: Tracheal intubation without neuromuscular blocking agents can be achieved safely and reliably by adding 7% sevoflurane to propofol (2 mg/kg) and remifentanil (1 µg/kg).
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spelling pubmed-29264352010-08-25 The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents Kim, Wook Jong Choi, Seong Soo Kim, Doo Hwan Seo, Hye Jeong Suk, Eun Ha Ku, Seung Woo Park, Pyung Hwan Korean J Anesthesiol Clinical Research Article BACKGROUND: Propofol and remifentanil are used for tracheal intubation in the absence of neuromuscular blocking agents. We hypothesized that the addition of sevoflurane to propofol and remifentanil would improve intubation conditions and provide hemodynamic stability. METHODS: Seventy-six patients scheduled for elective surgery were randomly allocated to be ventilated with either 4% (group I) or 7% sevoflurane (group II) after propofol injection (2 mg/kg). All patients received remifentanil (1 µg/kg) 30 seconds after administration of propofol. Ninety seconds after remifentanil was given, laryngoscopy and tracheal intubation were performed. Intubation conditions and hemodynamic changes were evaluated. RESULTS: The overall incidence of clinically acceptable intubation conditions was significantly higher in group II (92%) than group I (58%) (P = 0.001). Scores for vocal cord position, coughing, and limb movement were significantly better in group II (P < 0.05). Mean blood pressure remained significantly lower than the pre-induction level throughout the investigation in both groups (P < 0.001), but there was no incidence of bradycardia or hypotension requiring treatment. CONCLUSIONS: Tracheal intubation without neuromuscular blocking agents can be achieved safely and reliably by adding 7% sevoflurane to propofol (2 mg/kg) and remifentanil (1 µg/kg). The Korean Society of Anesthesiologists 2010-08 2010-08-20 /pmc/articles/PMC2926435/ /pubmed/20740212 http://dx.doi.org/10.4097/kjae.2010.59.2.87 Text en Copyright © The Korean Society of Anesthesiologists, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Kim, Wook Jong
Choi, Seong Soo
Kim, Doo Hwan
Seo, Hye Jeong
Suk, Eun Ha
Ku, Seung Woo
Park, Pyung Hwan
The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title_full The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title_fullStr The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title_full_unstemmed The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title_short The effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
title_sort effects of sevoflurane with propofol and remifentanil on tracheal intubation conditions without neuromuscular blocking agents
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926435/
https://www.ncbi.nlm.nih.gov/pubmed/20740212
http://dx.doi.org/10.4097/kjae.2010.59.2.87
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