Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

Polycomb group (PcG) proteins are transcriptional repressors, which regulate proliferation and cell fate decisions during development, and their deregulated expression is a frequent event in human tumours. The Polycomb repressive complex 2 (PRC2) catalyzes trimethylation (me3) of histone H3 lysine 2...

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Detalles Bibliográficos
Autores principales: Pasini, Diego, Malatesta, Martina, Jung, Hye Ryung, Walfridsson, Julian, Willer, Anton, Olsson, Linda, Skotte, Julie, Wutz, Anton, Porse, Bo, Jensen, Ole Nørregaard, Helin, Kristian
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926606/
https://www.ncbi.nlm.nih.gov/pubmed/20385584
http://dx.doi.org/10.1093/nar/gkq244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926606/
https://www.ncbi.nlm.nih.gov/pubmed/20385584
http://dx.doi.org/10.1093/nar/gkq244

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