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Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters

Antigene RNAs (agRNAs) are small RNA duplexes that target non-coding transcripts rather than mRNA and specifically suppress or activate gene expression in a sequence-dependent manner. For many applications in vivo, it is likely that agRNAs will require chemical modification. We have synthesized agRN...

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Detalles Bibliográficos
Autores principales:	Watts, Jonathan K., Yu, Dongbo, Charisse, Klaus, Montaillier, Christophe, Potier, Pierre, Manoharan, Muthiah, Corey, David R.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926613/ https://www.ncbi.nlm.nih.gov/pubmed/20403811 http://dx.doi.org/10.1093/nar/gkq258

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