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Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice

PURPOSE: Gastrointestinal mucositis, commonly associated with diarrhea, is a dose-limiting toxicity of chemotherapy. The new benzamidine derivative CR3294 reduces tissue damage in animal models of intestinal inflammation. Thus, we tested whether CR3294 had the potential to prevent chemotherapy-induc...

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Detalles Bibliográficos
Autores principales:	Letari, Ornella, Booth, Catherine, Bonazzi, Albino, Garofalo, Paolo, Makovec, Francesco, Rovati, Lucio C., Caselli, Gianfranco
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926937/ https://www.ncbi.nlm.nih.gov/pubmed/20041326 http://dx.doi.org/10.1007/s00280-009-1224-1

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