The Role of Lipids in Retrovirus Replication

Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the vir...

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Detalles Bibliográficos
Autores principales: Waheed, Abdul A., Freed, Eric O.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927015/
https://www.ncbi.nlm.nih.gov/pubmed/20740061
http://dx.doi.org/10.3390/v2051146
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author Waheed, Abdul A.
Freed, Eric O.
author_facet Waheed, Abdul A.
Freed, Eric O.
author_sort Waheed, Abdul A.
collection PubMed
description Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication.
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spelling pubmed-29270152010-08-24 The Role of Lipids in Retrovirus Replication Waheed, Abdul A. Freed, Eric O. Viruses Review Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication. Molecular Diversity Preservation International (MDPI) 2010-05-06 /pmc/articles/PMC2927015/ /pubmed/20740061 http://dx.doi.org/10.3390/v2051146 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Waheed, Abdul A.
Freed, Eric O.
The Role of Lipids in Retrovirus Replication
title The Role of Lipids in Retrovirus Replication
title_full The Role of Lipids in Retrovirus Replication
title_fullStr The Role of Lipids in Retrovirus Replication
title_full_unstemmed The Role of Lipids in Retrovirus Replication
title_short The Role of Lipids in Retrovirus Replication
title_sort role of lipids in retrovirus replication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927015/
https://www.ncbi.nlm.nih.gov/pubmed/20740061
http://dx.doi.org/10.3390/v2051146
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