Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

PURPOSE: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. METHODS: Western analysis, ELISA, and immunohistochemical analy...

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Autores principales: Cafaro, Thamara A., Santo, Stefanía, Robles, Lucena A., Crim, Nicolás, Urrets-Zavalia, Julio A., Serra, Horacio M.
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927370/
https://www.ncbi.nlm.nih.gov/pubmed/20806090
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author Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets-Zavalia, Julio A.
Serra, Horacio M.
author_facet Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets-Zavalia, Julio A.
Serra, Horacio M.
author_sort Cafaro, Thamara A.
collection PubMed
description PURPOSE: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. METHODS: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. RESULTS: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). CONCLUSIONS: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
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spelling pubmed-29273702010-08-30 Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve Cafaro, Thamara A. Santo, Stefanía Robles, Lucena A. Crim, Nicolás Urrets-Zavalia, Julio A. Serra, Horacio M. Mol Vis Research Article PURPOSE: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. METHODS: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. RESULTS: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). CONCLUSIONS: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline. Molecular Vision 2010-08-17 /pmc/articles/PMC2927370/ /pubmed/20806090 Text en Copyright © 2010 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets-Zavalia, Julio A.
Serra, Horacio M.
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_full Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_fullStr Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_full_unstemmed Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_short Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_sort peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927370/
https://www.ncbi.nlm.nih.gov/pubmed/20806090
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