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A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1

BACKGROUND: Polycomb group (PcG) proteins play a crucial role in cellular senescence as key transcriptional regulators of the Ink4a/Arf tumor suppressor gene locus. However, how PcG complexes target and contribute to stable gene silencing of the Ink4a/Arf locus remains little understood. METHODOLOGY...

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Detalles Bibliográficos
Autores principales:	Negishi, Masamitsu, Saraya, Atsunori, Mochizuki, Shinobu, Helin, Kristian, Koseki, Haruhiko, Iwama, Atsushi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927437/ https://www.ncbi.nlm.nih.gov/pubmed/20808772 http://dx.doi.org/10.1371/journal.pone.0012373

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