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Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927499/ https://www.ncbi.nlm.nih.gov/pubmed/20704708 http://dx.doi.org/10.1186/2041-9414-1-11 |
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author | Fenech, Michael F |
author_facet | Fenech, Michael F |
author_sort | Fenech, Michael F |
collection | PubMed |
description | DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability and DNA repair. In this paper I describe and propose the use of high-throughput nutrient array systems with high content analysis diagnostics of DNA damage, cell death and cell growth for defining, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. |
format | Text |
id | pubmed-2927499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29274992010-08-25 Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control Fenech, Michael F Genome Integr Review DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability and DNA repair. In this paper I describe and propose the use of high-throughput nutrient array systems with high content analysis diagnostics of DNA damage, cell death and cell growth for defining, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. BioMed Central 2010-08-12 /pmc/articles/PMC2927499/ /pubmed/20704708 http://dx.doi.org/10.1186/2041-9414-1-11 Text en Copyright ©2010 Fenech; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Fenech, Michael F Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title | Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title_full | Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title_fullStr | Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title_full_unstemmed | Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title_short | Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control |
title_sort | nutriomes and nutrient arrays - the key to personalised nutrition for dna damage prevention and cancer growth control |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927499/ https://www.ncbi.nlm.nih.gov/pubmed/20704708 http://dx.doi.org/10.1186/2041-9414-1-11 |
work_keys_str_mv | AT fenechmichaelf nutriomesandnutrientarraysthekeytopersonalisednutritionfordnadamagepreventionandcancergrowthcontrol |