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Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control

DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify...

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Detalles Bibliográficos
Autor principal: Fenech, Michael F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927499/
https://www.ncbi.nlm.nih.gov/pubmed/20704708
http://dx.doi.org/10.1186/2041-9414-1-11
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author Fenech, Michael F
author_facet Fenech, Michael F
author_sort Fenech, Michael F
collection PubMed
description DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability and DNA repair. In this paper I describe and propose the use of high-throughput nutrient array systems with high content analysis diagnostics of DNA damage, cell death and cell growth for defining, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control.
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spelling pubmed-29274992010-08-25 Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control Fenech, Michael F Genome Integr Review DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability and DNA repair. In this paper I describe and propose the use of high-throughput nutrient array systems with high content analysis diagnostics of DNA damage, cell death and cell growth for defining, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. BioMed Central 2010-08-12 /pmc/articles/PMC2927499/ /pubmed/20704708 http://dx.doi.org/10.1186/2041-9414-1-11 Text en Copyright ©2010 Fenech; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fenech, Michael F
Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title_full Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title_fullStr Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title_full_unstemmed Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title_short Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control
title_sort nutriomes and nutrient arrays - the key to personalised nutrition for dna damage prevention and cancer growth control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927499/
https://www.ncbi.nlm.nih.gov/pubmed/20704708
http://dx.doi.org/10.1186/2041-9414-1-11
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