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Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine

In mammals DNA methylation occurs at position 5 of cytosine in a CpG context and regulates gene expression. It plays an important role in diseases and inhibitors of DNA methyltransferases (DNMTs)—the enzymes responsible for DNA methylation—are used in clinics for cancer therapy. The most potent inhi...

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Detalles Bibliográficos
Autores principales:	Champion, Christine, Guianvarc'h, Dominique, Sénamaud-Beaufort, Catherine, Jurkowska, Renata Z., Jeltsch, Albert, Ponger, Loïc, Arimondo, Paola B., Guieysse-Peugeot, Anne-Laure
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927531/ https://www.ncbi.nlm.nih.gov/pubmed/20808780 http://dx.doi.org/10.1371/journal.pone.0012388

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