IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKβ activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKβ/NF-κB activation by a mechanism dependent...

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Detalles Bibliográficos
Autores principales: Ropelle, Eduardo R., Flores, Marcelo B., Cintra, Dennys E., Rocha, Guilherme Z., Pauli, José R., Morari, Joseane, de Souza, Claudio T., Moraes, Juliana C., Prada, Patrícia O., Guadagnini, Dioze, Marin, Rodrigo M., Oliveira, Alexandre G., Augusto, Taize M., Carvalho, Hernandes F., Velloso, Lício A., Saad, Mario J. A., Carvalheira, José B. C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927536/
https://www.ncbi.nlm.nih.gov/pubmed/20808781
http://dx.doi.org/10.1371/journal.pbio.1000465

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