Cargando…

Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation

BACKGROUND AND AIMS: Although Hnf1α is crucial for pancreas and liver functions, it is believed to play a limited functional role for intestinal epithelial functions. The aim of this study was to assess the consequences of abrogating Hnf1α on the maintenance of adult small intestinal epithelial func...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lussier, Carine R., Brial, François, Roy, Sébastien A. B., Langlois, Marie-Josée, Verdu, Elena F., Rivard, Nathalie, Perreault, Nathalie, Boudreau, François
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927538/ https://www.ncbi.nlm.nih.gov/pubmed/20808783 http://dx.doi.org/10.1371/journal.pone.0012378

Ejemplares similares

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression
por: Langlois, Marie-Josée, et al.
Publicado: (2010)

SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis
por: Coulombe, Geneviève, et al.
Publicado: (2016)

Loss of PTEN Signaling in Foxl1(+) Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice
por: Langlois, Marie-Josée, et al.
Publicado: (2019)

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
por: Bian, Benjamin, et al.
Publicado: (2015)

HDAC1 and HDAC2 Restrain the Intestinal Inflammatory Response by Regulating Intestinal Epithelial Cell Differentiation
por: Turgeon, Naomie, et al.
Publicado: (2013)

The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
por: Girard, Romain, et al.
Publicado: (2022)

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases
por: Gómez, Dianne Pupo, et al.
Publicado: (2021)

Loss of Sonic Hedgehog Leads to Alterations in Intestinal Secretory Cell Maturation and Autophagy
por: Gagné-Sansfaçon, Jessica, et al.
Publicado: (2014)

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis
por: Raisch, Jennifer, et al.
Publicado: (2021)

NCOR1 Sustains Colorectal Cancer Cell Growth and Protects against Cellular Senescence
por: St-Jean, Stéphanie, et al.
Publicado: (2021)

Fibrin(ogen) Is Constitutively Expressed by Differentiated Intestinal Epithelial Cells and Mediates Wound Healing
por: Seltana, Amira, et al.
Publicado: (2022)

SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
por: Gagné-Sansfaçon, Jessica, et al.
Publicado: (2016)

Dual‐specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis
por: Beaudry, Katia, et al.
Publicado: (2018)

ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells
por: Paquin, Marie-Christine, et al.
Publicado: (2013)

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis
por: Bergeron, Sébastien, et al.
Publicado: (2010)

The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring
por: Gaudet, Suzanne, et al.
Publicado: (2011)

Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells
por: Babeu, Jean-Philippe, et al.
Publicado: (2019)

The tyrosine phosphatase Shp‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration
por: Gagné‐Sansfacon, Jessica, et al.
Publicado: (2018)

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice
por: Gonneaud, Alexis, et al.
Publicado: (2021)

Plasmodium sporozoites can invade hepatocytic cells independently of the Ephrin receptor A2
por: Langlois, Anne-Claire, et al.
Publicado: (2018)

HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide
por: Girard, Romain, et al.
Publicado: (2019)

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice
por: Darsigny, Mathieu, et al.
Publicado: (2009)

Hepatocyte Nuclear Factor 4 Alpha Polymorphisms and the Metabolic Syndrome in French-Canadian Youth
por: Marcil, Valérie, et al.
Publicado: (2015)

Ulcerative Colitis–Associated Carcinoma: Epithelial SMAD4-Mediated Signaling Is a Key Guardian
por: Perreault, Nathalie
Publicado: (2018)

Hepatocyte Nuclear Factor-1β Induces Redifferentiation of Dedifferentiated Tubular Epithelial Cells
por: Omata, Mitsugu, et al.
Publicado: (2016)

Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha
por: Davison, James M., et al.
Publicado: (2017)

Epigenetics in Intestinal Epithelial Cell Renewal
por: Roostaee, Alireza, et al.
Publicado: (2016)

Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury
por: Lepage, David, et al.
Publicado: (2016)

Development of immortalized human hepatocyte-like hybrid cells by fusion of multi-lineage progenitor cells with primary hepatocytes
por: Collins, Daniel P., et al.
Publicado: (2020)

In vitro differentiation of rat mesenchymal stem cells to hepatocyte lineage
por: Sarvandi, Samaneh Solati, et al.
Publicado: (2015)

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
por: Ikpa, Pauline T., et al.
Publicado: (2016)

Lineage-Specific Expression of Bestrophin-2 and Bestrophin-4 in Human Intestinal Epithelial Cells
por: Ito, Go, et al.
Publicado: (2013)

RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt
por: Benoit, Yannick D., et al.
Publicado: (2012)

Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytes
por: Langlois, Anne-Claire, et al.
Publicado: (2020)

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration
por: Gonzalez, Liara M., et al.
Publicado: (2013)

A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers
por: Raisch, Jennifer, et al.
Publicado: (2019)

Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism
por: Benoit, Yannick D., et al.
Publicado: (2009)

Liver-enriched transcription factors are critical for the expression of hepatocyte marker genes in mES-derived hepatocyte-lineage cells
por: Kheolamai, Pakpoom, et al.
Publicado: (2009)

Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium
por: Marongiu, Fabio, et al.
Publicado: (2014)

Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells
por: Russ, Holger A., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_glqnoeuf6iompi6legt83juosh