Template-Directed Ligation of Tethered Mononucleotides by T4 DNA Ligase for Kinase Ribozyme Selection

BACKGROUND: In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species. While nucleic acid catalysis of phosphoryl transfer is well established for phosphorylation of 5′ or 2′ OH o...

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Detalles Bibliográficos
Autores principales: Nickens, David G., Bardiya, Nirmala, Patterson, James T., Burke, Donald H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927549/
https://www.ncbi.nlm.nih.gov/pubmed/20811490
http://dx.doi.org/10.1371/journal.pone.0012368

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