Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo

BACKGROUND: Overexpression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is commonly occurred in cancers and causes radioresistance and poor prognosis. In present study, the single-chain variable antibody fragments (scFv) targeting DNA-PKcs was developed for the application of radiose...

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Detalles Bibliográficos
Autores principales: Du, Li, Zhou, Li-Jun, Pan, Xiu-Jie, Wang, Yu-Xiao, Xu, Qin-Zhi, Yang, Zhi-Hua, Wang, Yu, Liu, Xiao-Dan, Zhu, Mao-Xiang, Zhou, Ping-Kun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927608/
https://www.ncbi.nlm.nih.gov/pubmed/20704701
http://dx.doi.org/10.1186/1748-717X-5-70

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