Allosteric Remodelling of the Histone H3 Binding Pocket in the Pygo2 PHD Finger Triggered by Its Binding to the B9L/BCL9 Co-Factor

The Zn-coordinated PHD fingers of Pygopus (Pygo) proteins are critical for β-catenin-dependent transcriptional switches in normal and malignant tissues. They bind to methylated histone H3 tails, assisted by their BCL9 co-factors whose homology domain 1 (HD1) binds to the rear PHD surface. Although h...

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Detalles Bibliográficos
Autores principales: Miller, Thomas C.R., Rutherford, Trevor J., Johnson, Christopher M., Fiedler, Marc, Bienz, Mariann
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927781/
https://www.ncbi.nlm.nih.gov/pubmed/20637214
http://dx.doi.org/10.1016/j.jmb.2010.07.007

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