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β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass

OBJECTIVE: C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about β-cell failure in these mice. RESEARCH DESIGN AND METHODS: DIO mice were separated in two groups acco...

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Detalles Bibliográficos
Autores principales:	Peyot, Marie-Line, Pepin, Emilie, Lamontagne, Julien, Latour, Martin G., Zarrouki, Bader, Lussier, Roxane, Pineda, Marco, Jetton, Thomas L., Madiraju, S.R. Murthy, Joly, Erik, Prentki, Marc
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927940/ https://www.ncbi.nlm.nih.gov/pubmed/20547980 http://dx.doi.org/10.2337/db09-1452

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