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Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

OBJECTIVE: To document the properties of the voltage-gated ion channels in human pancreatic α-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS: Glucagon release was measured from intact islets. [Ca(2+)](i) was recorded in cells showing spontaneous activity at 1 mmol/l glucose. M...

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Detalles Bibliográficos
Autores principales:	Ramracheya, Reshma, Ward, Caroline, Shigeto, Makoto, Walker, Jonathan N., Amisten, Stefan, Zhang, Quan, Johnson, Paul R., Rorsman, Patrik, Braun, Matthias
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927942/ https://www.ncbi.nlm.nih.gov/pubmed/20547976 http://dx.doi.org/10.2337/db09-1505

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