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Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice

OBJECTIVE: To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN AND METHODS: We backcrossed the Ins2(Akita) mutatio...

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Detalles Bibliográficos
Autores principales:	Brehm, Michael A., Bortell, Rita, diIorio, Philip, Leif, Jean, Laning, Joseph, Cuthbert, Amy, Yang, Chaoxing, Herlihy, Mary, Burzenski, Lisa, Gott, Bruce, Foreman, Oded, Powers, Alvin C., Greiner, Dale L., Shultz, Leonard D.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927949/ https://www.ncbi.nlm.nih.gov/pubmed/20570944 http://dx.doi.org/10.2337/db10-0323

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