Cargando…

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

OBJECTIVE: Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic factor and therapeutic target for diabetic retinopathy (DR). Since VEGF has been proposed as a survival factor for retinal neurons, defining the cellular origin of pathogenic VEGF is necessary for the effectiveness...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Juanjuan, Xu, Xueliang, Elliott, Michael H., Zhu, Meili, Le, Yun-Zheng
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927953/ https://www.ncbi.nlm.nih.gov/pubmed/20530741 http://dx.doi.org/10.2337/db09-1420

Ejemplares similares

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
por: Zhong, Yimin, et al.
Publicado: (2012)

Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice
por: Miller, William P., et al.
Publicado: (2022)

VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes
por: Le, Yun-Zheng, et al.
Publicado: (2021)

CD40 in Retinal Müller Cells Induces P2X(7)-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
por: Clermont, Allen, et al.
Publicado: (2011)

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
por: Thounaojam, Menaka C., et al.
Publicado: (2019)

Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function
por: Miller, Antonia G., et al.
Publicado: (2010)

Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy
por: Chronopoulos, Argyrios, et al.
Publicado: (2015)

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α
por: Zheng, Zhi, et al.
Publicado: (2010)

Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy
por: McVicar, Carmel M., et al.
Publicado: (2011)

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1
por: He, Chaoyong, et al.
Publicado: (2015)

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice
por: Gil, Natali, et al.
Publicado: (2012)

Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition
por: Huang, Hu, et al.
Publicado: (2015)

Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels
por: Tecilazich, Francesco, et al.
Publicado: (2020)

Nitrite Anion Therapy Protects Against Chronic Ischemic Tissue Injury in db/db Diabetic Mice in a NO/VEGF-Dependent Manner
por: Bir, Shyamal C., et al.
Publicado: (2014)

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
por: Aranda, Jorge, et al.
Publicado: (2012)

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
por: Giacco, Ferdinando, et al.
Publicado: (2014)

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models
por: Opreanu, Madalina, et al.
Publicado: (2011)

mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
por: Fort, Patrice E., et al.
Publicado: (2014)

Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction
por: Kalani, Anuradha, et al.
Publicado: (2015)

Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
por: Chen, Jianglei, et al.
Publicado: (2021)

Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow
por: Bhatwadekar, Ashay D., et al.
Publicado: (2013)

Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema
por: Sun, Jennifer K., et al.
Publicado: (2015)

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes
por: Vasam, Goutham, et al.
Publicado: (2017)

Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes
por: Leal, Ermelindo C., et al.
Publicado: (2010)

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice
por: Mzhavia, Nino, et al.
Publicado: (2008)

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy
por: Vulesevic, Branka, et al.
Publicado: (2016)

Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization
por: Al-Shabrawey, Mohamed, et al.
Publicado: (2011)

MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy
por: McArthur, Kara, et al.
Publicado: (2011)

Metabolic Phenotypes, Vascular Complications, and Premature Deaths in a Population of 4,197 Patients With Type 1 Diabetes
por: Mäkinen, Ville-Petteri, et al.
Publicado: (2008)

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy
por: Rajesh, Mohanraj, et al.
Publicado: (2012)

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation
por: Ko, Kang I., et al.
Publicado: (2019)

Differentiating Microaneurysm Pathophysiology in Diabetic Retinopathy Through Objective Analysis of Capillary Nonperfusion, Inflammation, and Pericytes
por: An, Dong, et al.
Publicado: (2022)

Serum Vascular Adhesion Protein-1 Predicts 10-Year Cardiovascular and Cancer Mortality in Individuals With Type 2 Diabetes
por: Li, Hung-Yuan, et al.
Publicado: (2011)

Transient Inhibition of Transforming Growth Factor-β1 in Human Diabetic CD34(+) Cells Enhances Vascular Reparative Functions
por: Bhatwadekar, Ashay D., et al.
Publicado: (2010)

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice
por: Watson, Anna M.D., et al.
Publicado: (2012)

Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain
por: Navaratna, Deepti, et al.
Publicado: (2011)

LTB(4)-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes
por: Bonyek-Silva, Icaro, et al.
Publicado: (2021)

Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats
por: Shibata, Taiga, et al.
Publicado: (2008)

Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice
por: Li, Guangyuan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4ir1gi0ede498otv9ecggcd3ud