Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α

OBJECTIVE: Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. The aim of this study was to clarify the beneficial effects and mechanism of acti...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Zhi, Chen, Haibing, Wang, Hong, Ke, Bilian, Zheng, Bingqing, Li, Qian, Li, Peiyu, Su, Li, Gu, Qing, Xu, Xun
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927955/
https://www.ncbi.nlm.nih.gov/pubmed/20566666
http://dx.doi.org/10.2337/db10-0638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927955/
https://www.ncbi.nlm.nih.gov/pubmed/20566666
http://dx.doi.org/10.2337/db10-0638

Ejemplares similares