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Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α

OBJECTIVE: Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. The aim of this study was to clarify the beneficial effects and mechanism of acti...

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Detalles Bibliográficos
Autores principales:	Zheng, Zhi, Chen, Haibing, Wang, Hong, Ke, Bilian, Zheng, Bingqing, Li, Qian, Li, Peiyu, Su, Li, Gu, Qing, Xu, Xun
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927955/ https://www.ncbi.nlm.nih.gov/pubmed/20566666 http://dx.doi.org/10.2337/db10-0638

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