Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability

BACKGROUND: Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (TGFbetaRII), BAX, hMSH3 and hMSH6. It is not clear how mutations of these ge...

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Detalles Bibliográficos
Autores principales: Yashiro, Masakazu, Hirakawa, Kosei, Boland, C Richard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927997/
https://www.ncbi.nlm.nih.gov/pubmed/20565851
http://dx.doi.org/10.1186/1471-2407-10-303

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