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The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit

The ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated at prometaphase by mitotic phosphorylation and binding of its activator, Cdc20. This initiates cyclin A degradation, whereas cyclin B1 is stabilized by the spindle checkpoint. Upon checkpoint release, the RXXL destruction...

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Detalles Bibliográficos
Autores principales:	van Zon, Wouter, Ogink, Janneke, ter Riet, Bas, Medema, René H., te Riele, Hein, Wolthuis, Rob M.F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928021/ https://www.ncbi.nlm.nih.gov/pubmed/20733055 http://dx.doi.org/10.1083/jcb.200912084

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