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Molecular mechanism of the synaptotagmin–SNARE interaction in Ca(2+)-triggered vesicle fusion

In neurons, SNAREs, synaptotagmin, and other factors catalyze Ca(2+)-triggered fusion of vesicles with the plasma membrane. The molecular mechanism of this process remains an enigma, especially regarding the interaction between synaptotagmin and SNAREs. Here we characterized this interaction by sing...

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Detalles Bibliográficos
Autores principales: Vrljic, Marija, Strop, Pavel, Ernst, James A., Sutton, R. Bryan, Chu, Steven, Brunger, Axel T.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928146/
https://www.ncbi.nlm.nih.gov/pubmed/20173762
http://dx.doi.org/10.1038/nsmb.1764