Cargando…
Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928270/ https://www.ncbi.nlm.nih.gov/pubmed/20811623 http://dx.doi.org/10.1371/journal.pone.0012371 |
_version_ | 1782185847213260800 |
---|---|
author | Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Zhang, Muxun Yao, Ping Hao, Liping Yang, Nianhong Hu, Frank B. Liu, Liegang |
author_facet | Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Zhang, Muxun Yao, Ping Hao, Liping Yang, Nianhong Hu, Frank B. Liu, Liegang |
author_sort | Bao, Wei |
collection | PubMed |
description | BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P<0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P<0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55–12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. CONCLUSIONS: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications. |
format | Text |
id | pubmed-2928270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29282702010-09-01 Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Zhang, Muxun Yao, Ping Hao, Liping Yang, Nianhong Hu, Frank B. Liu, Liegang PLoS One Research Article BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P<0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P<0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55–12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. CONCLUSIONS: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications. Public Library of Science 2010-08-25 /pmc/articles/PMC2928270/ /pubmed/20811623 http://dx.doi.org/10.1371/journal.pone.0012371 Text en Bao et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Zhang, Muxun Yao, Ping Hao, Liping Yang, Nianhong Hu, Frank B. Liu, Liegang Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title | Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title_full | Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title_fullStr | Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title_full_unstemmed | Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title_short | Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus |
title_sort | plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928270/ https://www.ncbi.nlm.nih.gov/pubmed/20811623 http://dx.doi.org/10.1371/journal.pone.0012371 |
work_keys_str_mv | AT baowei plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT songfangfang plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT lixiangyang plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT rongshuang plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT yangwei plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT zhangmuxun plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT yaoping plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT haoliping plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT yangnianhong plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT hufrankb plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus AT liuliegang plasmahemeoxygenase1concentrationiselevatedinindividualswithtype2diabetesmellitus |