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Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases...

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Autores principales: Bao, Wei, Song, Fangfang, Li, Xiangyang, Rong, Shuang, Yang, Wei, Zhang, Muxun, Yao, Ping, Hao, Liping, Yang, Nianhong, Hu, Frank B., Liu, Liegang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928270/
https://www.ncbi.nlm.nih.gov/pubmed/20811623
http://dx.doi.org/10.1371/journal.pone.0012371
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author Bao, Wei
Song, Fangfang
Li, Xiangyang
Rong, Shuang
Yang, Wei
Zhang, Muxun
Yao, Ping
Hao, Liping
Yang, Nianhong
Hu, Frank B.
Liu, Liegang
author_facet Bao, Wei
Song, Fangfang
Li, Xiangyang
Rong, Shuang
Yang, Wei
Zhang, Muxun
Yao, Ping
Hao, Liping
Yang, Nianhong
Hu, Frank B.
Liu, Liegang
author_sort Bao, Wei
collection PubMed
description BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P<0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P<0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55–12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. CONCLUSIONS: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications.
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spelling pubmed-29282702010-09-01 Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Zhang, Muxun Yao, Ping Hao, Liping Yang, Nianhong Hu, Frank B. Liu, Liegang PLoS One Research Article BACKGROUND: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). METHODS AND FINDINGS: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P<0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P<0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55–12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. CONCLUSIONS: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications. Public Library of Science 2010-08-25 /pmc/articles/PMC2928270/ /pubmed/20811623 http://dx.doi.org/10.1371/journal.pone.0012371 Text en Bao et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bao, Wei
Song, Fangfang
Li, Xiangyang
Rong, Shuang
Yang, Wei
Zhang, Muxun
Yao, Ping
Hao, Liping
Yang, Nianhong
Hu, Frank B.
Liu, Liegang
Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title_full Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title_fullStr Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title_full_unstemmed Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title_short Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
title_sort plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928270/
https://www.ncbi.nlm.nih.gov/pubmed/20811623
http://dx.doi.org/10.1371/journal.pone.0012371
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