Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

BACKGROUND: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequ...

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Detalles Bibliográficos
Autores principales: Hov, Johannes R., Keitel, Verena, Laerdahl, Jon K., Spomer, Lina, Ellinghaus, Eva, ElSharawy, Abdou, Melum, Espen, Boberg, Kirsten M., Manke, Thomas, Balschun, Tobias, Schramm, Christoph, Bergquist, Annika, Weismüller, Tobias, Gotthardt, Daniel, Rust, Christian, Henckaerts, Liesbet, Onnie, Clive M., Weersma, Rinse K., Sterneck, Martina, Teufel, Andreas, Runz, Heiko, Stiehl, Adolf, Ponsioen, Cyriel Y., Wijmenga, Cisca, Vatn, Morten H., Stokkers, Pieter C. F., Vermeire, Severine, Mathew, Christopher G., Lie, Benedicte A., Beuers, Ulrich, Manns, Michael P., Schreiber, Stefan, Schrumpf, Erik, Häussinger, Dieter, Franke, Andre, Karlsen, Tom H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928275/
https://www.ncbi.nlm.nih.gov/pubmed/20811628
http://dx.doi.org/10.1371/journal.pone.0012403

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