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No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial
OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928344/ https://www.ncbi.nlm.nih.gov/pubmed/20805274 http://dx.doi.org/10.2337/dc10-0814 |
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author | Bizzarri, Carla Pitocco, Dario Napoli, Nicola Di Stasio, Enrico Maggi, Daria Manfrini, Silvia Suraci, Concetta Cavallo, Maria Gisella Cappa, Marco Ghirlanda, Giovanni Pozzilli, Paolo |
author_facet | Bizzarri, Carla Pitocco, Dario Napoli, Nicola Di Stasio, Enrico Maggi, Daria Manfrini, Silvia Suraci, Concetta Cavallo, Maria Gisella Cappa, Marco Ghirlanda, Giovanni Pozzilli, Paolo |
author_sort | Bizzarri, Carla |
collection | PubMed |
description | OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (aged 11–35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 μg/day calcitriol or placebo and followed-up for 2 years. RESULTS: At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS: At the doses used, calcitriol is ineffective in protecting β-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. |
format | Text |
id | pubmed-2928344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-29283442011-09-01 No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial Bizzarri, Carla Pitocco, Dario Napoli, Nicola Di Stasio, Enrico Maggi, Daria Manfrini, Silvia Suraci, Concetta Cavallo, Maria Gisella Cappa, Marco Ghirlanda, Giovanni Pozzilli, Paolo Diabetes Care Original Research OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (aged 11–35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 μg/day calcitriol or placebo and followed-up for 2 years. RESULTS: At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS: At the doses used, calcitriol is ineffective in protecting β-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. American Diabetes Association 2010-09 /pmc/articles/PMC2928344/ /pubmed/20805274 http://dx.doi.org/10.2337/dc10-0814 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Bizzarri, Carla Pitocco, Dario Napoli, Nicola Di Stasio, Enrico Maggi, Daria Manfrini, Silvia Suraci, Concetta Cavallo, Maria Gisella Cappa, Marco Ghirlanda, Giovanni Pozzilli, Paolo No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title_full | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title_fullStr | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title_full_unstemmed | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title_short | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
title_sort | no protective effect of calcitriol on β-cell function in recent-onset type 1 diabetes: the imdiab xiii trial |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928344/ https://www.ncbi.nlm.nih.gov/pubmed/20805274 http://dx.doi.org/10.2337/dc10-0814 |
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