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Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes

OBJECTIVE: We have reported that renal hyperfiltration is associated with endothelial dysfunction in early type 1 diabetes. However, the relationship between renal hyperfiltration and arterial stiffness is unknown. Accordingly, we measured arterial stiffness in type 1 diabetic subjects with hyperfil...

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Autores principales: Cherney, David Z.I., Sochett, Etienne B., Lai, Vesta, Dekker, Maria G., Slorach, Cameron, Scholey, James W., Bradley, Timothy J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928365/
https://www.ncbi.nlm.nih.gov/pubmed/20585001
http://dx.doi.org/10.2337/dc10-0767
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author Cherney, David Z.I.
Sochett, Etienne B.
Lai, Vesta
Dekker, Maria G.
Slorach, Cameron
Scholey, James W.
Bradley, Timothy J.
author_facet Cherney, David Z.I.
Sochett, Etienne B.
Lai, Vesta
Dekker, Maria G.
Slorach, Cameron
Scholey, James W.
Bradley, Timothy J.
author_sort Cherney, David Z.I.
collection PubMed
description OBJECTIVE: We have reported that renal hyperfiltration is associated with endothelial dysfunction in early type 1 diabetes. However, the relationship between renal hyperfiltration and arterial stiffness is unknown. Accordingly, we measured arterial stiffness in type 1 diabetic subjects with hyperfiltering (n = 20) or normofiltering (n = 18). RESEARCH DESIGN AND METHODS: Augmentation index (AIx), aortic pulse wave velocity (PWV), renal hemodynamic function (inulin and paraaminohippurate clearances), and urinary and circulating plasma cGMP were measured in normoalbuminuric subjects with type 1 diabetes during clamped euglycemia (glucose 4–6 mmol/l) and hyperglycemia (glucose 9–11 mmol/l). RESULTS: During clamped euglycemia, hyperfiltering subjects (glomerular filtration rate ≥135 ml/min/1.73 m(2)) exhibited lower AIx values (−6.1 ± 2.9 vs. 13.9 ± 2.7%, P = 0.001) and higher cGMP levels in urine and plasma compared with normofiltering subjects. These differences were maintained during clamped hyperglycemia. As expected, renal hemodynamic responses to clamped hyperglycemia were exaggerated in normofilterers, but values for AIx remained unchanged. CONCLUSIONS: Renal hyperfiltration is associated with reduced arterial stiffness in subjects with uncomplicated type 1 diabetes.
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spelling pubmed-29283652011-09-01 Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes Cherney, David Z.I. Sochett, Etienne B. Lai, Vesta Dekker, Maria G. Slorach, Cameron Scholey, James W. Bradley, Timothy J. Diabetes Care Original Research OBJECTIVE: We have reported that renal hyperfiltration is associated with endothelial dysfunction in early type 1 diabetes. However, the relationship between renal hyperfiltration and arterial stiffness is unknown. Accordingly, we measured arterial stiffness in type 1 diabetic subjects with hyperfiltering (n = 20) or normofiltering (n = 18). RESEARCH DESIGN AND METHODS: Augmentation index (AIx), aortic pulse wave velocity (PWV), renal hemodynamic function (inulin and paraaminohippurate clearances), and urinary and circulating plasma cGMP were measured in normoalbuminuric subjects with type 1 diabetes during clamped euglycemia (glucose 4–6 mmol/l) and hyperglycemia (glucose 9–11 mmol/l). RESULTS: During clamped euglycemia, hyperfiltering subjects (glomerular filtration rate ≥135 ml/min/1.73 m(2)) exhibited lower AIx values (−6.1 ± 2.9 vs. 13.9 ± 2.7%, P = 0.001) and higher cGMP levels in urine and plasma compared with normofiltering subjects. These differences were maintained during clamped hyperglycemia. As expected, renal hemodynamic responses to clamped hyperglycemia were exaggerated in normofilterers, but values for AIx remained unchanged. CONCLUSIONS: Renal hyperfiltration is associated with reduced arterial stiffness in subjects with uncomplicated type 1 diabetes. American Diabetes Association 2010-09 2010-06-28 /pmc/articles/PMC2928365/ /pubmed/20585001 http://dx.doi.org/10.2337/dc10-0767 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Cherney, David Z.I.
Sochett, Etienne B.
Lai, Vesta
Dekker, Maria G.
Slorach, Cameron
Scholey, James W.
Bradley, Timothy J.
Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title_full Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title_fullStr Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title_full_unstemmed Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title_short Renal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
title_sort renal hyperfiltration and arterial stiffness in humans with uncomplicated type 1 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928365/
https://www.ncbi.nlm.nih.gov/pubmed/20585001
http://dx.doi.org/10.2337/dc10-0767
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