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Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS)
OBJECTIVE: Disposition index (DI) and glucose effectiveness (S(G)) are risk factors for diabetes. However, the effect of DI and S(G) on future diabetes has not been examined in large epidemiological studies using direct measures. RESEARCH DESIGN AND METHODS: Insulin sensitivity index (S(I)), acute i...
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928371/ https://www.ncbi.nlm.nih.gov/pubmed/20805282 http://dx.doi.org/10.2337/dc10-0165 |
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author | Lorenzo, Carlos Wagenknecht, Lynne E. Rewers, Marian J. Karter, Andrew J. Bergman, Richard N. Hanley, Anthony J.G. Haffner, Steven M. |
author_facet | Lorenzo, Carlos Wagenknecht, Lynne E. Rewers, Marian J. Karter, Andrew J. Bergman, Richard N. Hanley, Anthony J.G. Haffner, Steven M. |
author_sort | Lorenzo, Carlos |
collection | PubMed |
description | OBJECTIVE: Disposition index (DI) and glucose effectiveness (S(G)) are risk factors for diabetes. However, the effect of DI and S(G) on future diabetes has not been examined in large epidemiological studies using direct measures. RESEARCH DESIGN AND METHODS: Insulin sensitivity index (S(I)), acute insulin response (AIR), and S(G) were measured in 826 participants (aged 40–69 years) in the Insulin Resistance Atherosclerosis Study (IRAS) by the frequently sampled intravenous glucose tolerance test. DI was expressed as S(I) × AIR. At the 5-year follow-up examination, 128 individuals (15.5%) had developed diabetes. RESULTS: The area under the receiver operating characteristic curve of a model with S(I) and AIR was similar to that of DI (0.767 vs. 0.774, P = 0.543). In a multivariate logistic regression model that included both DI and S(G), conversion to diabetes was predicted by both S(G) (odds ratio × 1 SD, 0.61 [0.47–0.80]) and DI (0.68 [0.54–0.85]) after adjusting for demographic variables, fasting and 2-h glucose concentrations, family history of diabetes, and measures of obesity. Age, sex, race/ethnicity, glucose tolerance status, obesity, and family history of diabetes did not have a significant modifying impact on the relation of S(G) and DI to incident diabetes. CONCLUSIONS: The predictive power of DI is comparable to that of its components, S(I) and AIR. S(G) and DI independently predict conversion to diabetes similarly across race/ethnic groups, varying states of glucose tolerance, family history of diabetes, and obesity. |
format | Text |
id | pubmed-2928371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-29283712011-09-01 Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) Lorenzo, Carlos Wagenknecht, Lynne E. Rewers, Marian J. Karter, Andrew J. Bergman, Richard N. Hanley, Anthony J.G. Haffner, Steven M. Diabetes Care Original Research OBJECTIVE: Disposition index (DI) and glucose effectiveness (S(G)) are risk factors for diabetes. However, the effect of DI and S(G) on future diabetes has not been examined in large epidemiological studies using direct measures. RESEARCH DESIGN AND METHODS: Insulin sensitivity index (S(I)), acute insulin response (AIR), and S(G) were measured in 826 participants (aged 40–69 years) in the Insulin Resistance Atherosclerosis Study (IRAS) by the frequently sampled intravenous glucose tolerance test. DI was expressed as S(I) × AIR. At the 5-year follow-up examination, 128 individuals (15.5%) had developed diabetes. RESULTS: The area under the receiver operating characteristic curve of a model with S(I) and AIR was similar to that of DI (0.767 vs. 0.774, P = 0.543). In a multivariate logistic regression model that included both DI and S(G), conversion to diabetes was predicted by both S(G) (odds ratio × 1 SD, 0.61 [0.47–0.80]) and DI (0.68 [0.54–0.85]) after adjusting for demographic variables, fasting and 2-h glucose concentrations, family history of diabetes, and measures of obesity. Age, sex, race/ethnicity, glucose tolerance status, obesity, and family history of diabetes did not have a significant modifying impact on the relation of S(G) and DI to incident diabetes. CONCLUSIONS: The predictive power of DI is comparable to that of its components, S(I) and AIR. S(G) and DI independently predict conversion to diabetes similarly across race/ethnic groups, varying states of glucose tolerance, family history of diabetes, and obesity. American Diabetes Association 2010-09 /pmc/articles/PMC2928371/ /pubmed/20805282 http://dx.doi.org/10.2337/dc10-0165 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Lorenzo, Carlos Wagenknecht, Lynne E. Rewers, Marian J. Karter, Andrew J. Bergman, Richard N. Hanley, Anthony J.G. Haffner, Steven M. Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title | Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title_full | Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title_fullStr | Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title_full_unstemmed | Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title_short | Disposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study (IRAS) |
title_sort | disposition index, glucose effectiveness, and conversion to type 2 diabetes: the insulin resistance atherosclerosis study (iras) |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928371/ https://www.ncbi.nlm.nih.gov/pubmed/20805282 http://dx.doi.org/10.2337/dc10-0165 |
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