A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide...

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Detalles Bibliográficos
Autores principales: Agudo, Rubén, Ferrer-Orta, Cristina, Arias, Armando, de la Higuera, Ignacio, Perales, Celia, Pérez-Luque, Rosa, Verdaguer, Nuria, Domingo, Esteban
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://www.ncbi.nlm.nih.gov/pubmed/20865120
http://dx.doi.org/10.1371/journal.ppat.1001072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://www.ncbi.nlm.nih.gov/pubmed/20865120
http://dx.doi.org/10.1371/journal.ppat.1001072

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