Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

Despite abundant expression of DNA methyltransferases (Dnmt’s) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We find that Dnmt3a expression is regulated in mouse nucleus accumbens (NAc) by chronic cocaine and chronic social defeat stress. Moreover, NAc spe...

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Detalles Bibliográficos
Autores principales: LaPlant, Quincey, Vialou, Vincent, Covington, Herbert E, Dumitriu, Dani, Feng, Jian, Warren, Brandon, Maze, Ian, Dietz, David M, Watts, Emily L., Iñiguez, Sergio D, Koo, Ja Wook, Mouzon, Ezekiell, Renthal, William, Hollis, Fiona, Wang, Hui, Noonan, Michele A., Ren, Yanhua, Eisch, Amelia J., Bolaños, Carlos A., Kabbaj, Mohamed, Xiao, Guanghua, Neve, Rachael L, Hurd, Yasmin L, Oosting, Ronald S, Fan, Gouping, Morrison, John H., Nestler, Eric J
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928863/
https://www.ncbi.nlm.nih.gov/pubmed/20729844
http://dx.doi.org/10.1038/nn.2619

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