Cargando…

Topoisomerase IIα maintains genomic stability through decatenation G(2) checkpoint signaling

Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry due to in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bower, Jacquelyn J., Karaca, Gamze F., Zhou, Yingchun, Simpson, Dennis A., Cordeiro-Stone, Marila, Kaufmann, William K.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928865/ https://www.ncbi.nlm.nih.gov/pubmed/20562910 http://dx.doi.org/10.1038/onc.2010.232

Ejemplares similares

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

The decatenation checkpoint
por: Damelin, M, et al.
Publicado: (2007)

Condensin aids sister chromatid decatenation by topoisomerase II
por: Charbin, Adrian, et al.
Publicado: (2014)

Binding of two DNA molecules by type II topoisomerases for decatenation
por: Kumar, Rupesh, et al.
Publicado: (2012)

Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification
por: Seol, Yeonee, et al.
Publicado: (2013)

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression
por: Ramamoorthy, Mahesh, et al.
Publicado: (2012)

Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
por: Gardner, Lauren, et al.
Publicado: (2011)

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events
por: Kristoffersen, Emil L., et al.
Publicado: (2017)

Leishmania actin binds and nicks kDNA as well as inhibits decatenation activity of type II topoisomerase
por: Kapoor, Prabodh, et al.
Publicado: (2010)

Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III
por: Terekhova, Ksenia, et al.
Publicado: (2014)

Functional Analyses of the Toxoplasma gondii DNA Gyrase Holoenzyme: A Janus Topoisomerase with Supercoiling and Decatenation Abilities
por: Lin, Ting-Yu, et al.
Publicado: (2015)

DNA Damage Checkpoint Responses in the S Phase of Synchronized Diploid Human Fibroblasts
por: Chastain, Paul D, et al.
Publicado: (2015)

PTEN stabilizes TOP2A and regulates the DNA decatenation
por: Kang, Xi, et al.
Publicado: (2015)

How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation
por: Rawdon, Eric J., et al.
Publicado: (2016)

NFBD1/MDC1 Is Phosphorylated by PLK1 and Controls G2/M Transition through the Regulation of a TOPOIIα-Mediated Decatenation Checkpoint
por: Ando, Kiyohiro, et al.
Publicado: (2013)

Chromosomes with Two Intact Axial Cores Are Induced by G(2 )Checkpoint Override: Evidence That DNA Decatenation Is not Required to Template the Chromosome Structure
por: Andreassen, Paul R., et al.
Publicado: (1997)

DNA supercoiling and its role in DNA decatenation and unknotting
por: Witz, Guillaume, et al.
Publicado: (2010)

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
por: Williamson, Elizabeth A., et al.
Publicado: (2008)

Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenation
por: Racko, Dusan, et al.
Publicado: (2015)

Metnase/SETMAR: a domesticated primate transposase that enhances DNA repair, replication, and decatenation
por: Shaheen, Montaser, et al.
Publicado: (2010)

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
por: Bower, Jacquelyn J., et al.
Publicado: (2017)

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation
por: Wang, Lily Hui-Ching, et al.
Publicado: (2007)

Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis
por: Martin, Carol-Anne, et al.
Publicado: (2016)

Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G(1 )checkpoint function
por: Simpson, Dennis A, et al.
Publicado: (2005)

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3
por: Cejka, Petr, et al.
Publicado: (2010)

Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment
por: Murillo-Pineda, Marina, et al.
Publicado: (2016)

Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment
por: Murillo-Pineda, Marina, et al.
Publicado: (2014)

DNA replication and the GINS complex: localization on extended chromatin fibers
por: Cohen, Stephanie M, et al.
Publicado: (2009)

G(q) signaling in α cells is critical for maintaining euglycemia
por: Liu, Liu, et al.
Publicado: (2021)

Profiles of Global Gene Expression in Ionizing-Radiation–Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G(1) Checkpoint in a G(0)-like State of Quiescence
por: Zhou, Tong, et al.
Publicado: (2006)

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
por: Chan, Agnes L.-F., et al.
Publicado: (2009)

Two type I topoisomerases maintain DNA topology in human mitochondria
por: Menger, Katja E, et al.
Publicado: (2022)

Human topoisomerases and their roles in genome stability and organization
por: Pommier, Yves, et al.
Publicado: (2022)

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway
por: Mikhailov, Alexei, et al.
Publicado: (2004)

ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation
por: Kolb, Ryan H., et al.
Publicado: (2012)

The Coordinated Positive Regulation of Topoisomerase Genes Maintains Topological Homeostasis in Streptomyces coelicolor
por: Szafran, Marcin Jan, et al.
Publicado: (2016)

The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity
por: Fielding, Andrew B., et al.
Publicado: (2018)

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions
por: Bjornsti, Mary-Ann, et al.
Publicado: (2019)

Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation
por: Kolb, Ryan H., et al.
Publicado: (2023)

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands
por: Bossaert, Madeleine, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_msr33iatct068obr6nof5s46v0