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Topoisomerase IIα maintains genomic stability through decatenation G(2) checkpoint signaling

Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry due to in...

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Detalles Bibliográficos
Autores principales:	Bower, Jacquelyn J., Karaca, Gamze F., Zhou, Yingchun, Simpson, Dennis A., Cordeiro-Stone, Marila, Kaufmann, William K.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928865/ https://www.ncbi.nlm.nih.gov/pubmed/20562910 http://dx.doi.org/10.1038/onc.2010.232

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