Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2

Parvalbumin-expressing, fast-spiking basket cells play key roles in the generation of synchronous, rhythmic population activities in the hippocampus. Here we show that GABA(A) receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells are selectively modulated by the membrane...

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Detalles Bibliográficos
Autores principales: Földy, Csaba, Lee, Sang-Hun, Morgan, Robert J., Soltesz, Ivan
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928876/
https://www.ncbi.nlm.nih.gov/pubmed/20676104
http://dx.doi.org/10.1038/nn.2609
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author Földy, Csaba
Lee, Sang-Hun
Morgan, Robert J.
Soltesz, Ivan
author_facet Földy, Csaba
Lee, Sang-Hun
Morgan, Robert J.
Soltesz, Ivan
author_sort Földy, Csaba
collection PubMed
description Parvalbumin-expressing, fast-spiking basket cells play key roles in the generation of synchronous, rhythmic population activities in the hippocampus. Here we show that GABA(A) receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells are selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC–2. These data demonstrate a novel cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
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spelling pubmed-29288762011-03-01 Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2 Földy, Csaba Lee, Sang-Hun Morgan, Robert J. Soltesz, Ivan Nat Neurosci Article Parvalbumin-expressing, fast-spiking basket cells play key roles in the generation of synchronous, rhythmic population activities in the hippocampus. Here we show that GABA(A) receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells are selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC–2. These data demonstrate a novel cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons. 2010-08-01 2010-09 /pmc/articles/PMC2928876/ /pubmed/20676104 http://dx.doi.org/10.1038/nn.2609 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Földy, Csaba
Lee, Sang-Hun
Morgan, Robert J.
Soltesz, Ivan
Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title_full Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title_fullStr Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title_full_unstemmed Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title_short Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
title_sort regulation of fast-spiking basket cell synapses by the chloride channel clc–2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928876/
https://www.ncbi.nlm.nih.gov/pubmed/20676104
http://dx.doi.org/10.1038/nn.2609
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