Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation

Myc is activated in many tumours, yet, paradoxically, stimulates differentiation in mammalian epidermis. To test whether the epidermis responds differently to different levels of Myc, we treated K14MycER transgenic mice with a range of concentrations of the inducing agent, 4-hydroxy-tamoxifen (4OHT)...

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Detalles Bibliográficos
Autores principales: Berta, Melanie A, Baker, Christopher M, Cottle, Denny L, Watt, Fiona M
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929372/
https://www.ncbi.nlm.nih.gov/pubmed/20043278
http://dx.doi.org/10.1002/emmm.200900047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929372/
https://www.ncbi.nlm.nih.gov/pubmed/20043278
http://dx.doi.org/10.1002/emmm.200900047

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