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Mobile genetic elements of Staphylococcus aureus

Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host. Mobile genetic elements (MGEs) play a central role in this adaptation process and are a means to transfer genetic informatio...

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Detalles Bibliográficos
Autores principales: Malachowa, Natalia, DeLeo, Frank R.
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929429/
https://www.ncbi.nlm.nih.gov/pubmed/20668911
http://dx.doi.org/10.1007/s00018-010-0389-4
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author Malachowa, Natalia
DeLeo, Frank R.
author_facet Malachowa, Natalia
DeLeo, Frank R.
author_sort Malachowa, Natalia
collection PubMed
description Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host. Mobile genetic elements (MGEs) play a central role in this adaptation process and are a means to transfer genetic information (DNA) among and within bacterial species. Importantly, MGEs encode putative virulence factors and molecules that confer resistance to antibiotics, including the gene that confers resistance to beta-lactam antibiotics in methicillin-resistant S. aureus (MRSA). Inasmuch as MRSA infections are a significant problem worldwide and continue to emerge in epidemic waves, there has been significant effort to improve diagnostic assays and to develop new antimicrobial agents for treatment of disease. Our understanding of S. aureus MGEs and the molecules they encode has played an important role toward these ends and has provided detailed insight into the evolution of antimicrobial resistance mechanisms and virulence.
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spelling pubmed-29294292010-09-10 Mobile genetic elements of Staphylococcus aureus Malachowa, Natalia DeLeo, Frank R. Cell Mol Life Sci Review Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host. Mobile genetic elements (MGEs) play a central role in this adaptation process and are a means to transfer genetic information (DNA) among and within bacterial species. Importantly, MGEs encode putative virulence factors and molecules that confer resistance to antibiotics, including the gene that confers resistance to beta-lactam antibiotics in methicillin-resistant S. aureus (MRSA). Inasmuch as MRSA infections are a significant problem worldwide and continue to emerge in epidemic waves, there has been significant effort to improve diagnostic assays and to develop new antimicrobial agents for treatment of disease. Our understanding of S. aureus MGEs and the molecules they encode has played an important role toward these ends and has provided detailed insight into the evolution of antimicrobial resistance mechanisms and virulence. SP Birkhäuser Verlag Basel 2010-07-29 2010 /pmc/articles/PMC2929429/ /pubmed/20668911 http://dx.doi.org/10.1007/s00018-010-0389-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Malachowa, Natalia
DeLeo, Frank R.
Mobile genetic elements of Staphylococcus aureus
title Mobile genetic elements of Staphylococcus aureus
title_full Mobile genetic elements of Staphylococcus aureus
title_fullStr Mobile genetic elements of Staphylococcus aureus
title_full_unstemmed Mobile genetic elements of Staphylococcus aureus
title_short Mobile genetic elements of Staphylococcus aureus
title_sort mobile genetic elements of staphylococcus aureus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929429/
https://www.ncbi.nlm.nih.gov/pubmed/20668911
http://dx.doi.org/10.1007/s00018-010-0389-4
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