The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex

The Fanconi Anemia pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and FANCD2 by the Fanconi Anemia core complex. Here we report the crystal structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex at 3.2 Å. The structure reve...

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Detalles Bibliográficos
Autores principales: Cole, Ambrose R., Lewis, Laurence P.C., Walden, Helen
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929457/
https://www.ncbi.nlm.nih.gov/pubmed/20154706
http://dx.doi.org/10.1038/nsmb.1759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929457/
https://www.ncbi.nlm.nih.gov/pubmed/20154706
http://dx.doi.org/10.1038/nsmb.1759

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