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Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels

Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n = 15) were collected at the time of sepsis diagnosis...

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Autores principales: Brenner, Thorsten, Rosenhagen, Claudia, Steppan, Jochen, Lichtenstern, Christoph, Weitz, Jürgen, Bruckner, Thomas, Martin, Eike O., Hoffmann, Ursula, Weigand, Markus A., Hofer, Stefan
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929618/
https://www.ncbi.nlm.nih.gov/pubmed/20847814
http://dx.doi.org/10.1155/2010/985614
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author Brenner, Thorsten
Rosenhagen, Claudia
Steppan, Jochen
Lichtenstern, Christoph
Weitz, Jürgen
Bruckner, Thomas
Martin, Eike O.
Hoffmann, Ursula
Weigand, Markus A.
Hofer, Stefan
author_facet Brenner, Thorsten
Rosenhagen, Claudia
Steppan, Jochen
Lichtenstern, Christoph
Weitz, Jürgen
Bruckner, Thomas
Martin, Eike O.
Hoffmann, Ursula
Weigand, Markus A.
Hofer, Stefan
author_sort Brenner, Thorsten
collection PubMed
description Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n = 15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n = 18) were collected once; samples from postoperative patients (n = 28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r (sp) = 0.720, ρ = 0.698/t24: r (sp) = 0.771, ρ = 0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
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spelling pubmed-29296182010-09-16 Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels Brenner, Thorsten Rosenhagen, Claudia Steppan, Jochen Lichtenstern, Christoph Weitz, Jürgen Bruckner, Thomas Martin, Eike O. Hoffmann, Ursula Weigand, Markus A. Hofer, Stefan Mediators Inflamm Clinical Study Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n = 15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n = 18) were collected once; samples from postoperative patients (n = 28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r (sp) = 0.720, ρ = 0.698/t24: r (sp) = 0.771, ρ = 0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response. Hindawi Publishing Corporation 2010 2010-08-05 /pmc/articles/PMC2929618/ /pubmed/20847814 http://dx.doi.org/10.1155/2010/985614 Text en Copyright © 2010 Thorsten Brenner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Brenner, Thorsten
Rosenhagen, Claudia
Steppan, Jochen
Lichtenstern, Christoph
Weitz, Jürgen
Bruckner, Thomas
Martin, Eike O.
Hoffmann, Ursula
Weigand, Markus A.
Hofer, Stefan
Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title_full Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title_fullStr Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title_full_unstemmed Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title_short Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
title_sort redox responses in patients with sepsis: high correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929618/
https://www.ncbi.nlm.nih.gov/pubmed/20847814
http://dx.doi.org/10.1155/2010/985614
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