TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy

BACKGROUND: Classical NF-κB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFα on skeletal muscle differentiation are mediated in part through sustained NF-κB activity. In dystrophic muscles, NF-κB activity is co...

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Detalles Bibliográficos
Autores principales: Acharyya, Swarnali, Sharma, Sudarshana M., Cheng, Alfred S., Ladner, Katherine J., He, Wei, Kline, William, Wang, Huating, Ostrowski, Michael C., Huang, Tim H., Guttridge, Denis C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930001/
https://www.ncbi.nlm.nih.gov/pubmed/20814569
http://dx.doi.org/10.1371/journal.pone.0012479

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