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CD8(+) T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

BACKGROUND: The objective of this study was to test the hypothesis that CD8(+) T cells directly mediate motor disability and axon injury in the demyelinated central nervous system. We have previously observed that genetic deletion of the CD8(+) T cell effector molecule perforin leads to preservation...

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Detalles Bibliográficos
Autores principales:	Deb, Chandra, LaFrance-Corey, Reghann G., Schmalstieg, William F., Sauer, Brian M., Wang, Huan, German, Christopher L., Windebank, Anthony J., Rodriguez, Moses, Howe, Charles L.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930011/ https://www.ncbi.nlm.nih.gov/pubmed/20814579 http://dx.doi.org/10.1371/journal.pone.0012478

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