Type I PIPK-α regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation

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Phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)) is a critical regulator of cell migration, but the roles of the type I phosphatidylinositol-4-phosphate 5-kinases (PIPKIs), which synthesize PI4,5P(2), have yet to be fully defined in this process. In this study, we report that one kinase, PIPKI-α, i...

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Detalles Bibliográficos
Autores principales: Chao, Wei-Ting, Daquinag, Alexes C., Ashcroft, Felicity, Kunz, Jeannette
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930278/
https://www.ncbi.nlm.nih.gov/pubmed/20660631
http://dx.doi.org/10.1083/jcb.200911110

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