Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

In chemotactic cells, G protein–coupled receptors activate Ras proteins, but it is unclear how Ras-associated pathways link extracellular signaling to cell migration. We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course of TORC2 (target of rapamycin [Tor] comple...

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Detalles Bibliográficos
Autores principales: Cai, Huaqing, Das, Satarupa, Kamimura, Yoichiro, Long, Yu, Parent, Carole A., Devreotes, Peter N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930282/
https://www.ncbi.nlm.nih.gov/pubmed/20660630
http://dx.doi.org/10.1083/jcb.201001129

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